In this work two sensitive areas of the Spanish coast located in the Atlantic (Ria de Vigo) and Mediterranean (Mar Menor lagoon) have been studied regarding their contamination by phthalates, organotin compounds and per- polyfluoroalkyl substances (seawater and sediments) in two different campaigns (spring and autumn in 2015). PFAS and OTCs were detected in seawater and sediments at low concentrations (few ng L-1 or ng g(-1)), whereas PAEs were detected at levels two orders of magnitude higher, particularly in Mar Menor lagoon due to its semi-confined characteristics. However, PAEs and OTCs concentration in sediments were higher in Ria de Vigo than in Mar Menor lagoon as a consequence of the influence of the important urban nuclei and port in that area.The ecological risk assessment revealed that in both areas tributyltin, dibutyltin and diethylphthalate pose a significant risk in sediments, whereas in seawater tributyltin in both areas resulted in a high risk. (C) 2021 Elsevier B.V. All rights reserved.