Heavy metal pollution is related to the fall in European eel (Anguilla anguilla) populations. The Mar Menor lagoon (SE Spain) is home to an endangered population of this species, which is still caught for human consumption. The presence of Pb, Cd and Hg in the livers and muscles and the Se:Hg ratio in muscle of 150 eels from this lagoon were determined. Pb concentrations were higher than those reported from other populations in the world, while Cd and Hg concentrations in the tissues analysed were lower. In terms of food safety, Se concentrations play an important role in sequestering Hg in eels from this lagoon.