Sewage management is a key issue within circular economy and climate change scenario. Ensuring water supply is a challenge on a global scale. Numerous projects for potable water reuse (indirect or direct) are carried out in different parts of the world. This territorial study analyzes the situation of sewage in the Campo de Cartagena - Mar Menor region (Southeastern Spain), an area with semi-arid Mediterranean climate with structural scarcity of water and high competition for the uses of water. With data provided by ESAMUR, the evolution of its performance, use of reclaimed water and the presence of pollutants at the entrance and exit of the STPs are examined. It concludes that the concentrations of parameters contemplated in Directive 91/271/EEC are met regardless of the greater or lesser presence in the inlet flow. It is convenient to advance with potable reuse pilot projects and greater investments.